Our's dust-free workshops specializing in the production of various types of biodegradable straws and disposable biodegradable tableware to prevent these products from any possible contamination during the manufacturing process. learn more We further investigated the interplay between fibroblasts and mEPCs by cell–cell communication analysis. ERF principally interacted with mEPCs via collagen family members and collagen receptor integrins α1β1/α2β1 (Supplementary Fig. S14). In contrast, IRF actively communicated with mEPCs through HLA-C, perhaps implying their capacity in antigen presentation (Supplementary Fig. S15). Besides, MIF-EGFR/TNFRSF14, IGF1/2-IGF1R/2 R, TNFSF12-TNFRSF12A (TWEAK-Fn14) interactions also mediated the crosstalk between TPF or SLF with EPCs, consistent with their function in facilitating tumor progression (Supplementary Figs. S16, S17 and Table S6). Todoric, J. & Karin, M. The fire within: cell-autonomous mechanisms in inflammation-driven cancer. Cancer Cell 35, 714–720 (2019).

Erdong Chen - Investment Banking Analyst - Evalueserve - LinkedIn Erdong Chen - Investment Banking Analyst - Evalueserve - LinkedIn

Ge, Y. et al. Stem cell lineage infidelity drives wound repair and cancer. Cell 169, 636–650.e14 (2017). Tian Y, Gu G, Johnson P, Rao T, Tsang T, Wang E (2018) Topological insulators for the generation of electron beams. Applied Physics Letters 113:233504. doi: 10.1063/1.5052415 Chiang JT, Haas JJ, Hu YC (2009) Secure and precise location verification using distance bounding and simultaneous multilateration. In: WISEC, pp 181–192Talevich, E., Shain, A. H., Botton, T. & Bastian, B. C. CNVkit: genome-wide copy number detection and visualization from targeted DNA sequencing. PLoS Comput. Biol. 12, e1004873 (2016). Guo, X. et al. Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing. Nat. Med. 24, 978–985 (2018). Roa, I. et al. Preneoplastic lesions and gallbladder cancer: an estimate of the period required for progression. Gastroenterology 111, 232–236 (1996).

Erdong Wang (0000-0001-8233-4941) - ORCID

Published by the American Physical Society under the terms of the Creative Commons Attribution 3.0 License. Further distribution of this work must maintain attribution to the author(s) and the published article’s title, journal citation, and DOI. Martinez, F. O. & Gordon, S. The M1 and M2 paradigm of macrophage activation: time for reassessment. F1000Prime Rep. 6, 13 (2014). Erdong Wang is a physicist in EIC directory. He is LV3 manager on strong hadron cooling for EIC. He earned his Ph.D in nuclear technology and application from Peking University at 2011. Then, he joined Brookhaven National Laboratory as a Goldhaber distinguish fellow. From 2016, he is a lead scientist of the electron source development group at Collider Accelerator Department, responsible forelectron source R&D and operation of photocathode growth systems. Erdong Wang's scientific expertise includes photocathodes, DC guns, beam dynamics, beamline commissioning, and SRF gun.Currently, his research focuses on the development of advanced, high-performance polarized/unpolarized electron sources, EIC electron cooler design and R&D. Niec, R. E., Rudensky, A. Y. & Fuchs, E. Inflammatory adaptation in barrier tissues. Cell 184, 3361–3375 (2021).We next compared DEGs between all the malignant and non-malignant EPCs (Fig. 2c; Supplementary Table S3). Upregulated genes in mEPCs, including IGF2, GPC3, S100A4, STMN1, and MDK, were semi-automatically assigned to the traditional cancer hallmark framework (Supplementary Table S4) 15, including proliferative signaling, invasion/metastasis, genomic instability, immune response, and stem cell-like program. We noted a multitude of genes mapping to chromatin remodeling, RNA metabolism, and protein homeostasis. Additionally, mEPCs extensively overexpressed gastrointestinal EPC markers (e.g., OLFM4, PHGR1) and cell differentiation markers (e.g., CD9, DLK1), implying the likelihood of gastrointestinal metaplasia 16, 17. These signatures were in line with enriched biological pathways (Fig. 2d) and coincidently exemplified the novel cancer hallmarks published during our peer review process 18. nEPCs highly expressed conserved cholangiocyte signatures (e.g., TFF2, FGF19, MUC5B) (Fig. 2c), typically engaged in physiological gallbladder functioning, as well as innate or adaptive immune responses against chronic inflammation (Fig. 2d; Supplementary Table S5). Based on SCENIC analysis, nEPCs showed highly active transcription factors (TFs) related to embryogenesis and organogenesis (e.g., HNF1B, NR2F1/2, SOX6) and bile acid metabolism ( NR1H4). 19 By contrast, mEPCs displayed oncogenic TF signatures mapping to MYC circuits (e.g., MYC, NELFE, HDAC2) or TP53-related pathways (Fig. 2e; Supplementary Fig. S3c and Table S6). Ben-Neriah, Y. & Karin, M. Inflammation meets cancer, with NF-kappaB as the matchmaker. Nat. Immunol. 12, 715–723 (2011). Lim, B., Lin, Y. & Navin, N. Advancing cancer research and medicine with single-cell genomics. Cancer Cell 37, 456–470 (2020). Zhang, Q. et al. Landscape and dynamics of single immune cells in hepatocellular carcinoma. Cell 179, 829–845.e20 (2019).

Restructuring and insolvency: PRC firms in China | Law firm Restructuring and insolvency: PRC firms in China | Law firm

von Locquenghien, M., Rozalen, C. & Celia-Terrassa, T. Interferons in cancer immunoediting: sculpting metastasis and immunotherapy response. J. Clin. Invest 131, e143296 (2021).Wang, X., Liu, C., Chen, J. et al. Single-cell dissection of remodeled inflammatory ecosystem in primary and metastatic gallbladder carcinoma. Hernandez-Fernaud, J. R. et al. Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity. Nat. Commun. 8, 14206 (2017). Efremova, M., Vento-Tormo, M., Teichmann, S. A. & Vento-Tormo, R. CellPhoneDB: inferring cell-cell communication from combined expression of multi-subunit ligand-receptor complexes. Nat. Protoc. 15, 1484–1506 (2020).